GIS Systems
Gastrointestinal simulations

GIS Systems were developed in the Pharmaceutical Biotechnology Laboratory of the Faculty of Biotechnology, UASVM Bucharest, Romania. Prof. Dr. Emanuel Vamanu coordinated the realization of the systems.

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The services provided in our laboratory, in collaboration with our partners,  are based on tests using the following systems:

  • GIS1 – single chamber system for in vitro simulation of the human gastrointestinal tract

  • GIS2 – in vitro simulation system of the human colon in three stages. The GIS2 system determines the real relation between various microbial strains of the human colon by simulating the conditions in each segment separately: ascending colon, transversal colon, and descending colon.

Main interest:

  • testing the intestinal transit for probiotic, prebiotic, and synbiotic products;

  • determining the in vitro effect of functional products on human colon microflora;

  • evaluation of different food ingredients and new food products;

  • evaluation of active ingredients and food supplements;

  • determination of the absorption, activation, and effect of pharmaceutical products in the human gastrointestinal tract;

  • different physicochemical, pharmaceutical, and pharmacognostic analyses;

  • isolation, identification, and tests of microbial strains (especially yeasts and lactic bacteria), but also medicinal mushrooms.